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Is obesity determined by genes? Change your unhealthy lifestyle

Obesity is a chronic metabolic disease that seriously affects human health, and it is the result of a combination of genetic and environmental factors. Changes in environmental factors promote the occurrence and development of obesity, while genetic factors play a crucial role in determining an individual’s susceptibility to obesity.

If we classify obesity into three categories: congenital inheritance, easy to gain weight after birth, and not easy to gain weight after birth, then we focus on the first two types. Congenital obesity is controlled by multiple genes, and abnormal fat metabolism is also a polygenic genetic disease; As for whether obesity will appear in the day after tomorrow, it is closely related to the “environment”, which includes various factors such as diet, exercise, medication, nerves, etc.

If we classify obesity into three categories: congenital inheritance, easy to gain weight after birth, and not easy to gain weight after birth, then we focus on the first two types. Congenital obesity is controlled by multiple genes, and abnormal fat metabolism is also a polygenic genetic disease; As for whether obesity will appear in the day after tomorrow, it is closely related to the “environment”, which includes various factors such as diet, exercise, medication, nerves, etc.

Due to the rapid development of gene sequencing technology, scientists can quickly obtain all the genes of a person (whole genome sequencing), and combine data from expression profiles and other levels to conduct multi-dimensional analysis such as network. Although some articles suggest finding so-called obesity factors, overall obesity is not a single gene, but multiple genes, with varying degrees of impact, And it is difficult to simply state that gene A affects 40% gene B affects 30%; The mechanism of living organisms is inherently complex, with both the control of the lower layer on the upper layer and the influence of the upper layer on the lower layer being intricate. Scientists find parts that are easy to control by humans but do not bring too many side effects, develop drugs or use other means to influence, solve diseases or achieve other goals that affect traits.

1. The FTO gene makes you “unable to shut up”
The FTO gene is a gene related to fat metabolism and obesity, widely distributed in various tissues of animals, and highly expressed in brain tissue, especially in the hypothalamus, which controls appetite. The FTO gene can affect the expression level of ghrelin, a peptide produced in the stomach that can enhance appetite, promote food intake, and regulate energy balance. Currently, Scientists can synthesize many of these peptides with the help of peptide manufacturers.  Research has shown that the SNP locus rs17817499 C allele of the FTO gene is positively correlated with the expression level of ghrelin in the blood, reducing post meal satiety, increasing food intake, and ultimately leading to obesity.

2. The SLC35D3 gene makes it difficult for you to step aside

Laziness is determined by genes rather than subjective will, and mutations in certain genes can lead to a tendency to be inactive. The study found that the SLC35D3 gene located on the side of D6S1009, the long arm of human chromosome 6, is closely related to body mass index (BMI). The protein defect encoded by this gene can lead to the blocking of the membrane transport of dopamine type I receptor in the striatum of the basal ganglia, and damage its signal pathway, resulting in reduced exercise and energy consumption, thus leading to obesity.

So, congenital obesity must be a genetic disease, determined by multiple genes, with related genes expressed or suppressed; People who are prone to gaining weight the day after tomorrow may belong to the “susceptible” population and are also controlled by genes, with insufficient or overexpression of related genes; The weight gain of other normal individuals is caused by normal acquired “environmental” factors.

Hold your mouth, step out of your legs, and make you lose weight

Of course, it is necessary to have a healthy eating habit, and secondly, actively participate in physical exercise. Exercise can restore the regulation of metabolism, stimulate body function, consume excess fat, and promote fat metabolism;

On the other hand, excess sugar is consumed and cannot be converted into fat, reducing the formation of fat; Exercise also adjusts the activity state of the cerebral cortex, makes you energetic, and increases your confidence in defeating obesity. Even though obesity is inextricably linked to genetics, there is always a way to find the right solution, which is also closely related to one’s own environment. In short, ‘keep your mouth shut and step out of your legs’ is the healthy truth in controlling obesity. Perhaps genetics gave you a T4 explosive, but the ultimate trigger will only be your unhealthy lifestyle.

My name is pengwei, I am a nationally certified licensed pharmacist who has been engaged in pharmaceutical research and development for 6 years. I hope my major will enable me to help more friends on Atoallinks platform!

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